Semaglutide dosage chart: every Wegovy and Ozempic dose, week by week

The Wegovy injection label starts at 0.25 mg once a week, steps up every 4 weeks, and reaches the 2.4 mg maintenance dose at week 17. Semaglutide has more schedules than most drugs because it comes in five forms: Wegovy injection, Wegovy HD, Wegovy tablets, Ozempic injection and the diabetes tablets. The tables below show what each label specifies, and your prescriber chooses the step and the pace.

Wegovy injection dosage chart

The maintenance dose depends on the reason for treatment:

• Weight reduction in adults: 2.4 mg (recommended) or 1.7 mg, with the option of 7.2 mg described above.
• Weight reduction in adolescents 12 and older: 2.4 mg (recommended) or 1.7 mg. The 7.2 mg dose is not labeled for them.
• Heart-risk reduction in adults: 2.4 mg (recommended) or 1.7 mg.
• MASH (fatty liver disease with scarring): 2.4 mg, reduced to 1.7 mg if not tolerated, with re-escalation to be considered.

In STEP 1, the trial behind the 2.4 mg dose, average weight loss was 14.9% at 68 weeks against 2.4% on placebo. The label’s 7.2 mg trial reported 18.8% at 72 weeks against 3.9%.

What happens at each dose step?

The early steps exist mostly to get your stomach used to the drug, and the side effects follow the climb. The Wegovy label says to follow the schedule “to reduce the risk of gastrointestinal adverse reactions.” A pooled analysis of the STEP trials on the semaglutide side effects page found stomach symptoms came most often during or shortly after a dose increase.

Reaching 2.4 mg is not a test you have to pass. The label lists 1.7 mg as a maintenance dose in its own right.

Wegovy pens and their concentrations

Every single-dose Wegovy pen delivers one fixed dose, so nothing is measured.

The June 2026 label also lists single-dose prefilled syringes for 0.25 mg to 2.4 mg, and a multi-dose FlexTouch pen holding 9.6 mg in 3 mL (3.2 mg/mL) that gives four 2.4 mg doses. The label says a FlexTouch pen must never be shared, even with a new needle, and that it is not recommended for self-injection by people who are visually impaired.

Wegovy pill dosage chart

How the label says to take it: one tablet each morning on an empty stomach, with no more than 4 ounces of plain water, swallowed whole. Then wait at least 30 minutes before eating, drinking or taking other oral medicines. Coffee, tea and juice do not count as water here, because the label says no other liquids. A missed tablet is skipped, not doubled.

The label allows switching from the 2.4 mg injection to the 25 mg tablet one week after the last shot, and from the 25 mg tablet to the 2.4 mg injection the day after the last tablet. If 25 mg tablets are not tolerated, it says to consider the 1.7 mg injection.

Ozempic dosage chart

Ozempic’s maintenance dose is 0.5, 1 or 2 mg, chosen by blood sugar response, and a step up is only for people who need more control. For the kidney use the label lists 1 mg. Ozempic multi-dose pens hold 3 mL each: the 2 mg pen (0.68 mg/mL) gives 0.25 mg or 0.5 mg doses, the 4 mg pen (1.34 mg/mL) gives 1 mg, and the 8 mg pen (2.68 mg/mL) gives 2 mg. The label also lists single-dose prefilled syringes of 0.25, 0.5 and 1 mg.

Ozempic tablets and Rybelsus: the diabetes pills

The two products are different formulations of oral semaglutide. The label says they “are not substitutable on a mg-to-mg basis”: Rybelsus 7 mg matches Ozempic tablets 4 mg, and Rybelsus 14 mg matches Ozempic tablets 9 mg. Both are approved for type 2 diabetes only. The Wegovy pill is a separate product for weight.

When and where do you take it?

Wegovy and Ozempic injections can go in at any time of day, with or without meals, on the same day each week. The label lists the abdomen, thigh or upper arm, and says the time of day and the site can change without changing the dose. Rotate the site with each dose.

To change your injection day, the Wegovy Medication Guide says your last dose must have been 2 or more days before. The Ozempic label says the same: at least 2 days between doses. The injection sites guide covers technique, and the dose tracker keeps your weeks straight.

What if you miss a dose?

For Wegovy injection, take a missed dose if the next one is more than 2 days away, and skip it if the next one is less than 2 days away. The rules differ by product, so do not assume they transfer:

Restarting after a break

If you missed 2 or more weekly Wegovy doses in a row, do not simply pick up where you left off. The label says to restart the escalation at a lower dose to reduce the risk of stomach side effects, and the Medication Guide says to contact your healthcare provider about how to restart. Which step you restart from is the prescriber’s call.

How many units is a dose of compounded semaglutide?

Divide the dose in mg by the vial’s concentration in mg/mL, then multiply by 100. Compounded semaglutide comes in multi-dose vials at a concentration the pharmacy sets, so the dose has to be converted into units on a U-100 insulin syringe.

The table uses two worked examples. A 5 mg/mL semaglutide product appears in a September 2026 FDA warning letter, and the FDA’s 2024 dosing-error alert describes 0.25 mg as 5 units, which is the same concentration.

The calculator above handles any other concentration, and the mg/mL to units converter works for other drugs. If your pharmacy sent a vial at another strength, these two columns do not apply to you. The compounded semaglutide guide explains what to check on the label.

Common semaglutide dosing mistakes

Most of these come straight from the labels or from FDA error reports.

• Reading units as milligrams. The FDA has reported patients who drew 50 units instead of 5, and prescribers who wrote 25 units when they meant 5.
• Doubling up after a missed dose. The label’s overdose effects are severe nausea, severe vomiting and severe low blood sugar. Poison Help is 1-800-222-1222.
• Resuming the old dose after a long gap. After 2 or more missed Wegovy doses, the label says to go back to a lower dose.
• Treating Rybelsus and Ozempic tablets as interchangeable. They are not, milligram for milligram.
• Taking the pill with coffee, or breaking it. The label says water only, and to swallow it whole, with no splitting, crushing or chewing.
• Taking more than one tablet a day. The label sets one a day.
• Combining products. The Wegovy label says it is not recommended with another semaglutide product or another GLP-1 drug.
• Sharing a multi-dose pen. Never, even with a new needle.
• Keeping a pen too long. A single-dose Wegovy pen can stay out of the fridge, at 46 to 86°F, for up to 28 days. An in-use FlexTouch or Ozempic pen is good for 56 days.

Who should not follow these schedules at all

Every semaglutide label carries a boxed warning about thyroid C-cell tumors seen in rodents. The labels say semaglutide must not be used by anyone with a personal or family history of medullary thyroid carcinoma or with Multiple Endocrine Neoplasia syndrome type 2, or after a serious allergic reaction to it. The label says its use in type 1 diabetes has not been evaluated, and it should not be combined with another GLP-1 drug. The label also advises stopping Wegovy at least 2 months before a planned pregnancy. The doses here describe what the labels say. Your prescriber decides what applies to you.